Protein–DNA interactions play central roles in many cellular processes. While many DNA-binding proteins, including transcription factors, bind to specific DNA sequences, other proteins exhibit no ...
This is a preview. Log in through your library . Abstract DNA is found in the cell largely as a negatively supercoiled molecule. This high-energy form of the genetic material can engender ...
The active uptake of extracellular DNA and its genomic integration is termed natural transformation and constitutes a major horizontal gene-transfer mechanism in prokaryotes. Chromosomal DNA ...
Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...
Some genome editing systems are highly conspicuous. They introduce double-strand breaks to DNA that attract the attention of cellular mechanisms such as nonhomologous end joining and homology-directed ...
Homology Medicines is adding an immunosuppressive regimen to a phase 1/2 trial for its phenylketonuria gene therapy, hoping to quell FDA concerns that triggered a clinical hold in February. The agency ...
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