Although it is an important technology for studying genomes, DNA sequencing was initially accomplished in 1977 by Frederick Sanger. Since its conception, the technology has developed rapidly. Alvaro G ...

Researchers at California NanoSystems Institute at UCLA, Stockholm University and Uppsala University are working on a smartphone-based microscope in hopes of developing a cost-effective and accessible ...

A research team led by the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a method to accurately and efficiently read DNA containing non-standard bases — a task once thought too ...

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at ...

DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...

When Matt Hill, PhD, was in graduate school, the human genome sequence was more or less finished and companies like 454 and Solexa were starting to make waves in next-gen sequencing (NGS). But Hill ...

This article explores limitations of chemical synthesis in high-throughput settings and the technical advantages enzymatic ...

The newest DNA sequencing technology from Swiss multinational Roche doesn’t measure DNA directly but in fact analyzes a different polymer altogether. The technology is not yet available for sale, but ...

Roche has put forward a new approach to genetic analysis, which it describes as sequencing-by-expansion—a proprietary method that pulls apart the DNA molecule and amplifies the signal of each ...

An international research collaboration has shed new light on how DNA sequence variation can influence gene activity in the developing human brain. The team, which was led by researchers at the ...

University researchers developed a new ligase, an enzyme that joins together strands of DNA or RNA and has applications in biotechnology and diagnostics, as described in an Oct. 7 paper in RNA Biology ...