ascopubs.org

ARID1A mutation to define an immunologically active subgroup in patients with microsatellite-stable colorectal cancer.

Differences in the immune microenvironment between early and late-onset colon and rectal cancer. Feasibility and clinical impact of routine molecular testing of gastrointestinal (GI) cancers at a ...
ascopubs.org

Notch1 mutations to define a subgroup of adenoid cystic carcinoma (ACC): Tumor stage, propensity to bone and liver metastasis, risk of relapse, and overall survival.

Comparison of two large, genetically and clinically annotated head and neck cancer (HNC) cohorts (TCGA, CHGC) and differential treatment effects on TP53 mutated, as well as oral cavity cancers. This ...
Nature

Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition

In this study, we investigated the impact of BET bromodomain inhibition on epigenetic regulatory elements that define the phenotype and metabolic subtypes of melanoma. We provide evidence for a direct ...
Nature

Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia

There have been many efforts to differentiate different disorders within the syndrome of schizophrenia. Thus, symptom analyses suggest three symptom clusters (positive symptoms (an excess or ...