Experimentation is a vital part of the scientific method. Most problems in science require observation of the system at work and experimentation to elucidate information about how the system works. In ...

The classical design (factorial design, response surface design, etc.) may fail to meet our requirements due to an irregular design space, involving categorical variables, a nonstandard model, or ...

In a two-level factorial experiment, we consider construction of parallel-flats designs with two identical parallel flats that allow estimation of a set of specified ...

Space-filling designs such as Latin hypercube designs (LHDs) are widely used in computer experiments. However, finding an optimal LHD with good space-filling properties is computationally cumbersome.

Ethics committees and funding agencies often receive protocols that involve either too many or too few animals to answer the specific research question being investigated. It is evident that a greater ...