Mass spectrometry (MS) is already perhaps the most popular analytical chemistry tool in drug discovery and development. Its use is ubiquitous in bioanalytical laboratories for drug and metabolite ...
Electrospray ionization mass spectrometry (ESI-MS) has emerged as a pivotal analytical tool, enabling the gentle conversion of analytes in solution into gas-phase ions while minimising fragmentation.
EI was first developed by Dempster in 1918 2 and can be considered a fairly harsh method of molecule fragmentation and ionization. In EI, the molecules of the analyte must be in the vapor phase to ...
A popular technique that helps scientists deposit defined layers of tightly packed organic molecules onto solid surfaces is getting its first major update in more than 80 years. Researchers at ...
Current drug discovery workflows rely on the synthesis and bioactivity assessment of large compound libraries, both processes which heavily depend on high-throughput (HT) experimentation to be able to ...
α-Cleavage – The homolytic fragmentation is induced by a radical cation located at a hetero atom. Functional groups can be arranged by their ability to induce α-Cleavages. Allyl cleavage – Homolytic ...
MIT engineers have demonstrated the first fully 3D-printed, droplet-emitting electrospray engine. The device, which would be ideal for enabling small satellites to make in-orbit maneuvers, can be ...
What are the ionization techniques for mass spectrometry? Mass spectrometry (MS) plays a vital role in many aspects of our lives, from diagnosing illness and detecting food contaminants to fighting ...
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