By providing a direct window on the reaction, ITC offers researchers a better insight into the mechanisms by which enzyme inhibition proceeds. It is usually very challenging, and sometimes next to ...

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for ...

Angiotensin-converting–enzyme (ACE) inhibitors are effective in reducing the risk of heart failure, myocardial infarction, and death from cardiovascular causes in patients with left ventricular ...

Recent evidence suggests that natural products are much more than simply agents of “microbial warfare” and actually play critical roles in bacterial pathogenesis and communication. In particular, ...

In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, ...

New research could pave the way for treating malaria, among other serious diseases, by using a method that inhibits a particular calcium-regulated enzyme called calpain. While the enzyme is essential ...

An international study led by scientists at Flinders University and at South China University of Technology has uncovered a new vulnerability in prostate cancer cells that could help improve treatment ...

Emory University researchers led by Kyle Biegasiewicz have repurposed enzymes to produce diazo compounds from hydrazones under milder, greener conditions than traditional chemical methods (J. Am. Chem ...