ascopubs.org

Relationship of miR-140-5p expression and p53 function and contribution to prognosis prediction and treatment decision of patients with gastric cancer.

Phase 0/1 of positron emission tomography (PET) imaging agent [18F]-ODS2004436 as a marker of EGFR mutation in patients with non-small cell lung cancer (NSCLC). Comparison of the tumor mutation burden ...
The Scientist

The Structure and Functions of the p53 Pathway: Information Acquisition, Redundancy, and Connectivity

Since its discovery by Arnold Levine in 1979, the tumor protein p53 has transformed the field of cancer research. p53 signaling plays a key role in regulating the cell cycle, maintaining genome ...
GEN

mRNA Nanoparticles Restore p53 Function, Improve Immunotherapy Response

Researchers at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH) have used mRNA nanoparticles to reprogram the tumor microenvironment of liver cancer and restore the function ...
EurekAlert!

Phase transition inside the nucleus provides oncogenic function to mutant p53 in cancer

Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of ...
ascopubs.org

P53 Silencing and Mammosphere Formation in Breast Cancer Cells Harbouring P53 Gain-of-Function Mutations Trigger Epithelial-Mesenchymal Transition

Targeting the Tumour-Specific Spliceosome Through In Silico Virtual Screening for Discovery of New SF3B1 Small Molecule Inhibitors This is an ASCO Meeting Abstract from the 2018 World Cancer Congress ...
Targeted Oncology

The Paradox of Progress: Personalizing First-Line Therapy in CLL

Expert breaks down CLL frontline choices, IGHV and p53 risk, and what fits patient life. The treatment landscape for chronic ...