The recent identification of three broadly neutralizing antibodies (bnAbs) against gp120–gp41 interface epitopes has expanded the targetable surface on the HIV-1 envelope glycoprotein (Env) trimer. By ...

A new study from scientists at The Scripps Research Institute describes the high-resolution structure of the HIV protein responsible for recognition and infection of host cells. The studyis the first ...

Just how the human immunodeficiency virus type 1 (HIV-1) envelope trimer (a protein comprised of three subunits) assembles itself, then shifts its shape during infection has been difficult to define.

Scientists from Scripps Research and Los Alamos National Laboratory have devised a method for mapping in unprecedented detail the thickets of slippery sugar molecules that help shield HIV from the ...

Yet certain details of that virion assembly have been lacking for four decades. In a study published in the journal Proceedings of the National Academy of Sciences, Jamil Saad, Ph.D., and colleagues ...

Human immunodeficiency virus (HIV) is a globally devastating virus for which no effective vaccine currently exists, despite ongoing research efforts to create one. A significant arm of HIV research ...

HIV vaccine efforts have been slowed by the difficulty of getting neutralizing antibodies to target the correct locations of the diverse variants of HIV. Neutralizing antibodies are proteins produced ...

Despite several decades of research, a vaccine for HIV has remained out of reach. The virus is clever – it can evolve to avoid immune responses, meaning many different strains now circulate across the ...