Gas chromatography-mass spectrometric analyses of purified extracts from cultures of Rhizobium phaseoli wild-type strain 8002, grown in a non-tryptophan-supplemented liquid medium, demonstrated the ...

Plants produce an astonishing variety of chemical substances. Most of these metabolites are involved in chemical communication and serve to defend against pests, protect against pathogens, and attract ...

Developing seedlings of Catharanthus roseus were analyzed for appearance of tryptophan decarboxylase (TDC), strictosidine synthase (SS), N-methyltransferase (NMT) and O-acetyltransferase (DAT) enzyme ...

This review synthesizes progress in pathway optimization, regulatory rewiring, and microbial cell factory design that has ...

Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles -- frameworks made of ...

The proposed method is simple, mild, fast, and produces high yields, with the potential to inspire the development of new drugs and agrochemicals. Indolo[2,3-a]quinolizidine is a common structural ...

Stephacidin A and its congeners are a collection of secondary metabolites that possess intriguing structural motifs. They stem from unusual biosynthetic sequences that lead to the incorporation of a ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, ...

Making chemical handles that latch onto amino acids is a strategy used to make covalent drugs, antibody-drug conjugates, and biochemical probes. Cysteine and lysine are common points of attachment, ...