We often treat intestinal infections as an episode: a few days of symptoms, elimination of the pathogen, and recovery. In this view, the disease has a clear beginning and end. However, patient ...

While in vivo animal models are commonly employed for pharmacokinetic studies, they are often expensive, low in throughpu,t and typically fail to accurately replicate key characteristics of the human ...

Deep in the folds of the intestine, in microscopic pockets called crypts, a quiet surveillance system is always at work. Stem ...

Non-alcoholic fatty liver disease (NAFLD), characterized by excessive hepatic lipid accumulation, poses a high prevalence and can progress to cirrhosis and liver cancer. To enhance preventive and ...

A groundbreaking study conducted by Jun Sun’s research team at the University of Illinois Chicago has revealed a new and critical role of Axin1 in regulating intestinal epithelial development and ...

A study published in the journal Nature, led by Carlene Zindl, Ph.D., and C. Garrett Wilson in the research group of Casey Weaver, M.D., at the University of Alabama at Birmingham, brings new ...

In vivo, the intestinal epithelium interacts with the neighboring environment through complex crosstalk, which involves components such as the immune system, tissue microenvironment, and gut microbes.

A high-fiber diet is known to have several health benefits. Scientific studies point to protection against such diseases as cancer and diabetes. However, exactly how fiber interacts with the ...

This story is part of a series exploring human anatomy and physiology complexities. Each story in this collection showcases discoveries reshaping our understanding of the body's inner workings, ...