Though treatments are available, there is no cure or vaccine from HIV, which impacts about 38 million people worldwide. It's difficult to target the RNA genome of the HIV virus in part because it ...

Scientists at the Electron Bio-Imaging Centre (eBIC) at Diamond Light Source, in the U.K., have harnessed a new technique, using cryo-electron tomography (cryoET) and subtomogram averaging (STA) to ...

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

A computational model of the more than 26 million atoms in a DNA-packed viral capsid expands our understanding of virus structure and DNA dynamics, insights that could provide new research avenues and ...

A 3-D model of adeno-associated virus (AAV) capsid structure: AAV capsid sixty subunits assemble to generate the icosahedral symmetric virus capsid. The viral asymmetric unit of the capsid is bounded ...

Many pathogenic viruses require a specific structure to be infectious, and their proteins form that structure in vivo with remarkable fidelity. The dynamical process by which protein conformations are ...

Researchers at the University of Delaware, using supercomputing resources and collaborating with scientists at Indiana University, have gained new understanding of the virus that causes hepatitis B ...

The Purdue University team that cracked the Zika virus’s code last year have now determined the high-resolution structure of immature Zika virus, a step toward better understanding how the virus ...

The multiple protein subunits (green, purple and red) of the plant-infecting brome mosaic virus (left) have separate nucleation and growth phases similar to the MS2 bacteria-infecting virus (right).

Key PointsResearch on HIV's conical capsid that began over 25 years ago led to the development of lenacapavir, the world's ...