DNA is the blueprint of life. Genes encode proteins and serve as the body's basic components. However, building a functioning ...

Antisense oligonucleotides (ASOs), used to treat genetic diseases, can affect how cells repair damage to their DNA. This is ...

Getting DNA into a living cell sounds simple, until you remember the cell’s outer membrane acts like a guarded wall. DNA strands carry a negative charge, and they do not cross that wall easily.

Researchers developed e2MPRA, a high-throughput technique that simultaneously measures cis-regulatory element activity and ...

A research team from London examined the relationship between adenovirus-associated virus (AAV)-based vectors and liver ...

Flowering time determines reproductive success in perennial trees, yet the epigenetic mechanisms underlying sexual asynchrony remain poorly understood.

A fleeting DNA fold called i‑DNA can switch cancer‑related genes on and off, revealing a hidden structural weak point that ...

How does our DNA store the massive amount of information needed to build a human being? And what happens when it's stored incorrectly? Jesse Dixon, MD, Ph.D., has spent years studying the way this ...

Less than 2% of the genome codes for proteins; the rest, once called 'junk DNA', contains regulatory elements. Researchers analyzed 10,000 to reveal how variants shape gene activity.

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health ...