eLife

A translational transcriptomic signature of vaccine reactogenicity for the evaluation of novel formulations

This study proposes a cross-species transcriptomic framework to predict vaccine reactogenicity, with implications for preclinical vaccine safety assessment. The findings show that mouse muscle ...
eLife

Cytoplasmatic polyadenylation of mRNA by TENT5A is critical for enamel mineralization

This study reports an important and novel finding that TENT5A, an enzyme involved in fine-tuning poly(A) tail length on selected mRNAs, is required for proper enamel mineralization in mice. The ...
BMJ

Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis

2 EA SNA EPIS 4607, Autonomic Nervous System, University of Lyon, Saint-Etienne, France Background The health benefits of 150 min a week of moderate-to-vigorous-intensity physical activity (MVPA) in ...
BMJ

Prevalence of illness, poor mental health and sleep quality and low energy availability prior to the 2016 Summer Olympic Games

Objective Establish the prevalence of illness symptoms, poor sleep quality, poor mental health symptoms, low energy availability and stress-recovery state in an Olympic cohort late in the 3 months ...
BMJ Case Reports

Monoallelic PARN mutation presenting as pancytopenia, hepatic fibrosis and idiopathic pulmonary fibrosis

A woman in her late 20s presented with a 5-year history of progressive fatigue and generalised weakness. Examination revealed signs of premature ageing, anaemia, neuropathy and hepatosplenomegaly.
Chalkbeat

Despite recent efforts to make change, top colleges are still home to mostly wealthy students

Chalkbeat Ideas is a new section featuring reported columns on the big ideas and debates shaping American schools. Sign up for the Ideas newsletter to follow our work. It’s hardly news that America’s ...