Leronlimab-mediated CCR5 blockade modulates T-Cell exhaustion pathways and PD-L1 Biology relevant to ICI responseDurable Clinical Observations ...

A multi-institutional study led by researchers at UNC Lineberger Comprehensive Cancer Center, the Salk Institute for Biological Studies, and UC San Diego has uncovered new genetic rules that determine ...

As the first CAR-T treatment for an autoimmune disease draws ever closer, officials at the FDA have signaled a willingness to support the development of these novel cell therapies with a flexible ...

The development of humans and other animals unfolds gradually over time, with cells taking on specific roles and functions via a process called cell fate determination. The fate of individual cells, ...

ATALANTA-1 data presented at ASH 2025 showed remarkable response rates and rapid manufacturing with an investigational autologous CAR T-cell therapy. In this interview, Michael Wang, MD, comments on ...

A recent publication in Nature Medicine describes a novel immunotherapy targeting pancreatic cancer that has shown promising results in a first in-human phase 1/2 trial. The TACTOPS trial, which ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

We owe a lot to tissue resident memory T cells (T RM). These specialized immune cells are among the body's first responders to disease. Rather than coursing through the bloodstream-as many T cells ...

Please provide your email address to receive an email when new articles are posted on . A one-time infusion of BMS-986353, a CD19 CAR T-cell therapy, improved lung function and skin thickness.

Immune cells that have been genetically engineered to kill cancerous cells, known as CAR T-cells, have transformed the treatment of blood cancers such as leukaemia, but have proved largely ineffective ...

In 2006 immunologist Shimon Sakaguchi co-wrote an article in Scientific American that now feels prophetic. In the article, entitled “Peacekeepers of the Immune System,” Sakaguchi and his co-author, ...

GM announced on Friday that it’s ceasing work on next-generation fuel cell development through the HYDROTEC brand. HYDROTEC is the branding that GM has used previously for hydrogen fuel cell projects ...