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  1. About Down Syndrome - National Human Genome Research Institute

    Jun 29, 2017 · Most cases of Down syndrome are not inherited, but occur as random events during the formation of reproductive cells (eggs and sperm). An error in cell division called nondisjunction …

  2. Down syndrome - Wikipedia

    Down syndrome or sometimes Down's syndrome, [12] also known as Trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. [3] It is usually associated …

  3. Down syndrome: MedlinePlus Genetics

    Most cases of Down syndrome are not inherited. When the condition is caused by trisomy 21, the chromosomal abnormality occurs as a random event during the formation of reproductive cells in a …

  4. About Down Syndrome - National Institutes of Health (NIH)

    Jul 16, 2025 · Down syndrome is the most common genetic cause of intellectual disability, the most common autosomal trisomy, and one of the most visible and universally recognized genetic syndromes.

  5. Down syndrome - Symptoms and causes - Mayo Clinic

    Nov 12, 2024 · Down syndrome is a genetic condition caused when an unusual cell division results in an extra full or partial copy of chromosome 21. This extra genetic material causes the developmental …

  6. Down Syndrome | Birth Defects | CDC

    Dec 26, 2024 · Down syndrome is a condition in which a person has an extra copy of chromosome 21. Chromosomes are small "packages" of genes in the body's cells, which determine how the body …

  7. Down Syndrome: Symptoms & Causes - Cleveland Clinic

    Most people have 23 pairs of chromosomes within each cell in their body, for a total of 46. A person diagnosed with Down syndrome has an extra copy of chromosome 21, which means their cells …

  8. Is Down Syndrome Hereditary? The Role of Genetics

    Aug 5, 2025 · Explore the genetic basis of Down Syndrome. Understand why most cases are not inherited, but learn about the rare exceptions and family implications.

  9. Down Syndrome (Trisomy 21) - Pediatrics - MSD Manual Professional …

    Mar 29, 2021 · Down syndrome is an abnormality of chromosome 21 that can cause intellectual disability, microcephaly, short stature, and characteristic facies. Diagnosis is suggested by physical …

  10. Down syndrome - Harvard Health

    Jun 25, 2025 · Down syndrome is a disorder caused by having an extra chromosome. Chromosomes are pieces of DNA that have the blueprint for the human body. Normally a person has two copies of …