
About Down Syndrome - National Human Genome Research Institute
Jun 29, 2017 · Most cases of Down syndrome are not inherited, but occur as random events during the formation of reproductive cells (eggs and sperm). An error in cell division called nondisjunction …
Down syndrome - Wikipedia
Down syndrome or sometimes Down's syndrome, [12] also known as Trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. [3] It is usually associated …
Down syndrome: MedlinePlus Genetics
Most cases of Down syndrome are not inherited. When the condition is caused by trisomy 21, the chromosomal abnormality occurs as a random event during the formation of reproductive cells in a …
About Down Syndrome - National Institutes of Health (NIH)
Jul 16, 2025 · Down syndrome is the most common genetic cause of intellectual disability, the most common autosomal trisomy, and one of the most visible and universally recognized genetic syndromes.
Down syndrome - Symptoms and causes - Mayo Clinic
Nov 12, 2024 · Down syndrome is a genetic condition caused when an unusual cell division results in an extra full or partial copy of chromosome 21. This extra genetic material causes the developmental …
Down Syndrome | Birth Defects | CDC
Dec 26, 2024 · Down syndrome is a condition in which a person has an extra copy of chromosome 21. Chromosomes are small "packages" of genes in the body's cells, which determine how the body …
Down Syndrome: Symptoms & Causes - Cleveland Clinic
Most people have 23 pairs of chromosomes within each cell in their body, for a total of 46. A person diagnosed with Down syndrome has an extra copy of chromosome 21, which means their cells …
Is Down Syndrome Hereditary? The Role of Genetics
Aug 5, 2025 · Explore the genetic basis of Down Syndrome. Understand why most cases are not inherited, but learn about the rare exceptions and family implications.
Down Syndrome (Trisomy 21) - Pediatrics - MSD Manual Professional …
Mar 29, 2021 · Down syndrome is an abnormality of chromosome 21 that can cause intellectual disability, microcephaly, short stature, and characteristic facies. Diagnosis is suggested by physical …
Down syndrome - Harvard Health
Jun 25, 2025 · Down syndrome is a disorder caused by having an extra chromosome. Chromosomes are pieces of DNA that have the blueprint for the human body. Normally a person has two copies of …