p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …

Jun 29, 2025 · The p53 protein, often called “the guardian of the genome,” is a tumor suppressor that helps prevent cells from becoming cancerous. As a transcription factor, it can bind to DNA and …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

p53 p53 is a tumor suppressor gene and is commonly mutated in several human cancers. In routine diagnostic surgical pathology, mutation status is assessed based on p53 expression by IHC.

The p53 gene, also known as TP53, is located on chromosome 17. It produces the p53 protein, which plays a crucial role in maintaining cellular stability and normal biological processes.

The perturbation of p53 signaling pathways is required for the development of most cancers; however, it is now becoming clear that p53 has a much broader role in human health and diseases.

Apr 9, 2025 · This Review discusses the roles, mechanisms and physiological settings in which NACDs are regulated by p53, and their potential targeting for the treatment of human diseases.

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …