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1:56
YouTube
Organic Mechanisms
EDC Coupling Mechanism | Organic Chemistry
The mechanism for the peptide coupling of a carboxylic acid with an amine to yield an amide. EDC is used as the coupling agent in this reaction. Triethyl amine is used as a base in order to deprotonate the carboxylic acid while hydrochloric is added later in the reaction process in order to protonate a portion of the EDC that will later detach ...
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